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Elton’s AIDS foundation has raised more than $400 million over the years, but wants people to know that the fight is far from over.

Anne Aslett, CEO of the Elton John AIDS Foundation, said the charity sees itself as bringing together government officials and nonprofits to multiply the impact of their efforts to prevent disease.

One key change the charity is making is to merge separate arms in the United States and England into one operation with greater global reach. Aslett says the response to the disease in many countries like Russia, Malawi, and the Philippines is still driven by stigma and fear.

“We will focus on people who should have the means to protect themselves from infection but don’t and who are living with HIV and should be on treatment but aren’t,” she says. “We will reinforce their access to health care by fighting to remove harmful laws and change cultural stigmas that keep them in the shadows.

Elton and his husband, David Furnish, answered questions from the Chronicle about the lessons they’ve learned and some changes Aslett is guiding at the charity to deal with the evolving health threat.